Adlershofer Kolloquium Analytik

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Adlershofer Kolloquium Analytik

Dienstag, 06. Juni 2017 // 14.00 - 16.00

Bundesanstalt für Materialforschung und -prüfung

Richard-Willstätter-Straße 11, 12489 Berlin

Analytic City Adlershof

Label-free electronic (bio) sensing using functionalized graphene devices

Prof. Dr. Kannan Balasubramanian
Humboldt-Universität zu Berlin
Institut für Chemie
Mikro- und Nanoanalytik

Summary

Nano electronic devices are highly promising as on-chip (bio)sensors [1] that motivate the vision of portable and compact analysis systems for the direct detection of trace amounts of analytes and biomarkers at the point-of-use or point-of-care. In order that such sensors find an application, a number of challenges need to be overcome. In this context, we explore strategies to engineer the surface chemistry of individual graphene sheets and to obtain a better understanding and control of the physico-chemical properties of the nanostructure-liquid-interface. We have designed an electrochemical route for controlled surface functionalization of nano objects and analytical protocols that allow a stable and reliable electronic readout of the various phenomena occurring at the graphene-liquid-interface. The designed sensors not only allow the detection of small quantities of biomolecules (peptides) in steady state [2] but also enable the real-time measurement of the kinetics of biomolecular interactions, specifically the interaction of enzymes with immobilized substrate molecules [3].

[1] K. Balasubramanian, K. Kern, Adv. Mater. 26, 1154 (2014)
[2] T. Kurkina et al., ACS Nano 6, 5514 (2012)
[3] L. Zuccaro et al., ACS Nano 11, 11166 (2015)

nanoanalytik.hu-berlin.de