Tutorial on the analysis of liposomes and lipid nanoparticles published
PTB contributes to the measurement of key structural parameters for the characterisation of materials
Liposomes and lipid nanoparticles (LNPs) are frequently used as carriers in drug delivery and are able to encapsulate active substances such as nucleic acids and peptides and transport them to the site of treatment in the body. They enhance bioavailability, reduce toxicity and facilitate controlled release of the active ingredients.
As part of the METRINO (Metrology for Innovative Nanotherapeutics) project funded by EURAMET, an international team published a handbook on the chemical and structural characterisation of these nanoparticles. PTB has contributed to this effort with its expertise and instrumentation in the field of X-ray radiometry and X-ray scattering methods. These techniques were used to measure essential structural and dimensional parameters of the geometrically complex nanoparticles. A major challenge of the project is the establishment of harmonised metrological and analytical standards in order to provide reliable data sets for compliance with legal regulations and for quality control.
Publication:
C. Minelli et al., European Journal of Pharmaceutical Sciences 222 (2026)
https://doi.org/10.1016/j.ejps.2026.107556
Contact:
Christian Gollwitzer
Physikalisch-Technische Bundesanstalt (PTB)
Working Group 7.21 X-ray Radiometry
christian.gollwitzer(at)ptb.de
PTB press release, 12 June 2026